Begun during the presidency of Dwight D. Eisenhower, the mission of the Sister Cities program is to “promote peace through mutual respect, understanding, & cooperation — one individual, one community at a time”.

The Santa Fe Sister Cities Program consists of a Mayor-appointed and City Council-approved Sister Cities Advisory Committee and seven Sister City relationships. Santa Fe is a member of Sister Cities International and has existing Sister City relationships with:

Bukhara, Uzbekistan
Parral, Mexico
Santa Fe de la Vega, Granada, Spain
Sorrento, Italy
Tsuyama, Japan 
Holguin, Cuba
Zhang Jia Jie, Hunan Province, The People’s Republic of China.